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根本医学院余健秀研讨组发明m6A润色浏览卵白YTHDF2功效调控的新份子机制
2021-02-13 浏览( 来历: 
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2021年2月12日亚博网页版余健秀研讨组在Nucleic Acids Research杂志上在线颁发“SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs”论文(全文链接:https//)。该研讨揭露SUMO化润色是m6A润色浏览卵白YTHDF2功效调控的一个新份子机制,并说明了其在肿瘤产生中的首要感化。

rnashiyichuanxinxicongdnatongbaodaoluanbaizhideguantouguantou,jinchaoyantaozhiyuanyifamingxibaoneigeleirna(baohanrrna、trna、snrna、mrnahelncrnadeng)zhongcunzaiduozhonghuaxuerunse,n6-jiajixiangan(m6a)bianshicizhongdeyigezuishouyaoderunse。gairunsechanshenglichengyouyixilieluanbaifuhewudaochang,yantaozhiyuanjiangzheixieluanbaijieshuoweiwriter、eraserhereader,bieliduiyingm6arunsernadejiajizhuanyicuihuamei、qujiajihuameiheliulanluanbai。ythdf2zuoweirnashangm6arunsedeyigeshouyaoliulanluanbai,qihanyoudeythbujuyu,keyihuoxutetongxingdibianrenlianxim6arunsederna,bingjiedaohouzhejiangjie。m6arunsebianjicunzaiyugeleirnazhong,tebiezaiburuzhiwuxibaozhongmrnahelncrnashangzuiweifengshuo。m6arunsezairnadaixiegefangmianbaohanwendingxing、dingwei、jianjiehefanyidengjunqiguantoudediaoliganhua,jinerdaochangxibaogeleixingminggoudanglicheng。shiyi,dangm6arunsechanshenghenshishi,huizhishiduozhongjibingdechansheng。

余健秀研讨组一向努力于处置与肿瘤相干的卵白质润色(PTMs)和RNA润色功效机制的研讨。特别最近几年来,在卵白质润色调控RNA润色及代谢感化机制方面获得了一些立异性功效。比方,2018年发明m6A润色甲基化转移酶METTL3的SUMO化润色是调理其催化活性的一个首要机制(Du YZ#, Hou GF#et al.,Nucleic Acids Res, 2018),该研讨发明了m6A润色甲基化转移酶相干复合物的第一个卵白质润色的功效调控机制;2020年发明脱氧胆酸(DCA)促使METTL3从甲基化转移酶相干复合物METTL3-METTL14-WTAP中解离,引发初始pri-miR-92b的m6A润色程度下降,进而影响成熟miR-92b-3p的天生。随之,经由过程旌旗灯号轴miR-92b-3p/PTEN/PI3K-AKT按捺胆囊癌细胞的发展(Lin R et al.,Oncogene, 2020)。

zaizheixiegenbenshang,gaiyantaozuzheicixinfamingsumohuarunseyiyangkeyihuoxudiaolim6arunseliulanluanbaiythdf2degongxiao。tamenfaming,ythdf2keyihuoxuzaixibaoneichanshengsumohuarunse,bingzaiqueyangdengyingjiqiantixiamingxianjiaqiang。ythdf2desumohuarunseshouyaochanshengzaidi571weilaiansuancanjishang。jingyouguochengshenghua、xibaoxuechangshi、merip-seqherna-seqhexiaofenziannajidengduozhongxinshouyifangshi,zhengmingleythdf2desumohuarunsemingxianjiaqiangqiyum6a-mrnalianxicaineng,congerzengjindajubumrnachanshengjiangjie。tongshifaming,zheisumohuarunseweiyingxiangdaoythdf2defansuhuarunsejiqizaixibaoneidedingweideng。zuichu,tamenshuomingleythdf2desumohuarunsezengjinfeiaixibaodefazhan。ythdf2zuoweim6arunsedeyigehenshishouyaodeliulanluanbai,zaicizhiqianqibenshengongxiaodiaolijizhihaimeiyoumingbai。gaiyantaoanshenyuythdf2deluanbaizhifanyihourunse,chongshizhengmingythdf2keyihuoxuchanshengsumohuarunsebingyingxiangqigongxiao,jieluleluanbaizhifanyihourunseyurnahuaxuerunsezhijiandeshenmilianxiguanxidejingtaidiaokongwang䋞。zuichu,yantaozhiyuanyiweim6arunsexianggandewriter、eraserhereaderfuhewuzhongdeguantouluanbaiyenenggouchanshengbiedeptms(rufansuhua、linsuanhua、yixianhuadengyoudaibeifaming),bingzaitedingyingjiqiantihuobinglizhuangkuangxiajianjiedaochangm6arunsernadewendingxing、dingweihefanyigongxiaodengdediaoli。

yabowangyebanhouguofangboshi、zhaoxianfuyantaoyuanweigailunwendepeihediyizuozhe,yujianxiuyantaoyuan、yabowangyebancongshudijiuguominyabowangyebanzhongliukezhurenjiangbinchuanshouweipeihetongxinzuozhe。gaiyantaohuodeleguodutianranmixinjijinwei、guodukejibuzhongdianyanfamingmudengbangzhu。


 

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